Picture of Cotrim DS 800/160mg Tablet
Picture of Cotrim DS 800/160mg Tablet
Picture of Cotrim DS 800/160mg Tablet
Picture of Cotrim DS 800/160mg Tablet

Cotrim DS 800/160mg Tablet

Category: Pharmacy
SKU: BEP_955922
Seller: Best Buy Pharma
Tk 2.66
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Medicine Overview of Cotrim DS 800mg+160mg Tablet

Introduction
Cotrim DS is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection. Cotrim DS is a prescription medicine that is advised to be taken as suggested by the doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as an overdose of it may have harmful effects on your body. If you miss a dose, take it...
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Uses of Cotrim DS
  • Bacterial infections
Side effects of Cotrim DS
Common
  • Nausea
  • Vomiting
  • Skin rash
  • Allergic reaction
How to use Cotrim DS
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Cotrim DS is to be taken with food.
How Cotrim DS works
Cotrim DS is a combination of two antibiotics: Sulfamethoxazole and Trimethoprim. These antibiotics work by preventing the bacteria from producing folic acid, a nutrient required for bacterial multiplication. Together, they treat your infection effectively.
Quick Tips
  • You have been prescribed Cotrim DS for the treatment of many types of bacterial infections.
  • Finish the prescribed course of Cotrim DS, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
  • Stop taking Cotrim DS and inform your doctor if you develop skin rash/blisters or other unexplained skin reaction while taking Cotrim DS.
  • In case of long-term use, have regular monthly blood tests to monitor your blood cells as suggested by your doctor.
Brief Description
Indication
Upper and lower respiratory tract infections, Gastrointestinal tract infections, Renal and urinary tract infections, Skin and wound infections, Septicaemias
Adult Dose
Oral Acute exacerbations of chronic bronchitis ; Acute otitis media; Urinary tract infections, GI infections; Resp and urinary tract infections; Susceptible infections Adult: Tablet : 2 tablet of 480mg twice daily. In severe cases, 3 times/day. DS Tablet : 1 tablet (960mg) twice daily. Suspension : 1-2 teaspoonful twice daily. Pneumocystis (carinii) jiroveci pneumonia Up to 120 mg/kg/day in 2-4 divided doses for 14-21 days. Prophylaxis of Pneumocystis (carinii) jiroveci pneumonia 960 mg once daily for 7 days; 960 mg once daily 3 times wkly on alternate days; or 960 mg bid 3 times wkly on alternate days. Infection prophylaxis...
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Child Dose
Child: Oral 8–10 mg TMP/kg/day q12h 2 mg TMP/kg/day for UTI prophylaxis q24h 15–20 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia treatment q6–8h 150 mg TMP/m2/day, OR 5 mg TMP/kg/day for Pneumocystis (carinii) jiroveci pneumonia prophylaxis q12h, 3 times a week OR q24h
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Renal Dose
Renal impairment: CrCl (ml/min) Dosage Recommendation <15 Not recommended. 15-30 Half the standard dose.
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Contraindication
Known hypersensitivity to trimethoprim or sulfonamides; severe hepatic failure or marked liver parenchymal damage, jaundice; serious haematological disorders and porphyria; severe renal insufficiency where repeated measurements of the plasma concentration cannot be performed; history of drug-induced immune thrombocytopenia w/ use of trimethoprim and/or sulfonamides; megaloblastic anaemia due to folate deficiency. Neonates <6 wk, except for the treatment/prophylaxis of P. jiroveci in infants >4 wk. Treatment of Group A β-haemolytic streptococcia. Pregnancy, esp in the period prior to birth. Concomitant use w/ clozapine. Concomitant use w/ leucovorin for the treatment of P. jiroveci in HIV positive patients.
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Mode of Action
Co-trimoxazole exhibits the synergistic actions of its components (sulfamethoxazole and trimethoprim) by 10-fold. Sulfamethoxazole inhibits dihydrofolic acid formation from PABA, thus interfering with synthesis and growth of bacterial folic acid. Trimethoprim inhibits enzymes folic acid pathway, preventing the reaction of the dihydrolic acid to tetrahydrofolate. Co-trimoxazole possesses bactericidal effects against E coli, Klebsiella spp, Enterobacter spp, M morganii, P mirabilis, P vulgaris, H influenzae, Strep pneumoniae, Pneumocystis (carinii) jiroveci, Cyclospora spp.
Precaution
Patient w/ severe allergy, bronchial asthma, thyroid dysfunction. Renal and mild to moderate hepatic impairment. Lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, serum K, creatinine, BUN.
Side Effect
Allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalised allergic reactions, generalised skin eruptions, photosensitivity, conjunctival and scleral inj, pruritus, urticaria, rash, periarteritis nodosa, SLE; elevated serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhoea, anorexia; renal failure, interstitial nephritis, elevated BUN and serum creatinine, toxic nephrosis w/ oliguria and anuria; hyperkalaemia; aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache; hallucinations, depression, apathy, nervousness; dieresis, hypoglycaemia; arthralgia, myalgia; rhabdomyolysis; cough, shortness of breath, pulmonary infiltrates; weakness, fatigue, insomnia; QT prolongation, haemolysis, impaired phenylalanine metabolism. Potentially Fatal: Severe...
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Interaction
Reduced ciclosporin concentrations in blood when used concurrently. Increases toxicity of methotrexate. Inhibits phenytoin clearance. Potentiates warfarin and oral hypoglycaemics. Potentially Fatal: Co-admin with pyrimethamine causes megaloblastic anaemia. Enhancement of renal damage by ciclosporin.
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